This medication has its origin of discovery in the late 1980s. The employees of the pharmaceutical company Pfizer were developing a new medication for the relief of pain associated with angina pectoris, which is chest pain that occurs when the blood supply to the heart is insufficient. It was therefore intended to be used in minimizing the effects of angina.
In clinical trials conducted in the early 1990s, it was noted that sildenafil 100mg was not very effective in the treatment of angina. However, they noticed an unexpected side effect. A large number of the male participants in the study said that they were benefitting from better erections. It was then marketed to treat this condition under the brand name Viagra. It is now available worldwide at a low sildenafil 100mg price.
How It Works
Sildenafil 100mg acts by blocking the phosphodiesterase type 5 (PDE5) enzyme. PDE5 is an enzyme that is present in certain tissues of the human body, such as the smooth muscle of the penis. Usually, PDE5 is responsible for destroying cyclic guanosine monophosphate (cGMP), a molecule that is involved in the process of blood flow regulation.
During sexual arousal, it is normal for a man to release nitric oxide (NO) in the penis. NO activates the enzyme guanylate cyclase, which in turn raises the amount of cGMP. cGMP leads to the relaxation of muscles of the penile blood vessels, leading to the dilation of the vessels. Whereas PDE5 normally catalyses the breakdown of cGMP, sildenafil 100mg inhibits this enzyme’s activity.
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Online pharmacies are in high demand in the market today. The benefits they offer include accessibility and lower costs, which is important for many UK patients. The convenience that comes with online pharmacies is one of the biggest perks for patients. They do not have to travel to a physical pharmacy in order to get their medications, instead they can conveniently have medication delivered to their home.
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Potential Interactions
Due to the possibility of life-threatening reactions or the reduced efficacy of the drug, it is necessary to mention that sildenafil 100mg may interact with other drugs. The most important of these are nitrates, which are drugs often used in the management of chest pain (angina). If it is mixed with nitric oxide, donors, or isosorbide mononitrate, it can lead to a dangerous and even fatal drop in blood pressure.
This interaction is so unsafe, that it is completely unadvisable for anyone taking nitrates. Another thing that a man should be careful of is any form of interaction with alpha-blockers, which are used in the management of hypertension and prostate related diseases.
Proven Effective
Sildenafil 100mg is the one of the few drugs that have been approved for the treatment of erectile dysfunction by the U.S Food and Drug Administration (FDA). It must be pointed out that the approval by the FDA means that it has been clinically tested for its safety, efficacy, and quality.
The FDA has one of the most rigorous approval processes in the world, which requires going through several phases of clinical research, and a complete analysis of the pros and cons of the drug. It received the approval of the FDA back in 1998, and it was the first effective oral medication for ED. The approval was therefore a great advancement in the management of ED, and offered a painless and affordable sildenafil 100mg price for millions of men.
The Importance of Patient Reviews
Patient reviews of sildenafil 100mg are important in many ways, particularly during the process of decision making in the health sector. These are practical experiences that are not recorded in clinical trials. These experiences are useful in managing the medication, as well as dealing with side effects. While clinical trials are critical in proving the safety and efficacy of drugs, they are usually conducted under controlled conditions in a certain type of patient.
Patient feedback is real-life experience from different people with different health conditions, lifestyles, and genetic predispositions. Such reviews may shed light on how a drug behaves among certain people, not in the ‘sterile’ environment of a trial. They can also be helpful to let people know where to find the lowest sildenafil 100mg price.
Conclusion
Impotence remains a major health concern in the UK, effecting almost every male as they grow older. Research shows that about half of the men between the ages of 40-70 experience erectile dysfunction, and this is equivalent to about 4. 3 million men in the UK. ED becomes more frequent in men as they get older, especially above 40 years of age. The expected prevalence of ED by 2025 is likely to be 322 million males worldwide.
Fortunately, there is hope for these men. Sildenafil 100mg is now available at our online pharmacy, and has never been more affordable. Patients can order this treatment using their smart phone, and have it quickly delivered to their door. Embrace the future of healthcare by clicking the link below and visiting our website.
Author Bio
Dr. Michael Stevens is a renowned urologist in the UK who has worked at several prestigious hospitals in London. His hard work and innovative approach to men’s health has garnered attention from the medical community, and he is often called upon to give advice on major research projects. Throughout his 15 years as a doctor, he has helped to integrate new technology into the field of urology, which has helped to improve patient outcomes.
He is a member of the UK Urology Association, and often gives lectures on the latest advances in treatment. He has a deep knowledge of how the male reproductive system works. For men’s health tips, follow him on x.com and LinkedIn.
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